Faculty 教員紹介

二木 啓フタツギ アキラ

専門基礎科学領域医科学分野教授
E-mail
futatsugiNo spam@tr.kobe-ccn.ac.jp

メッセージ

専門知識や技術とともに、対象を多面的に観察して柔軟に考える姿勢を大切にし たいと思います。自分の感性に問いながら、試行錯誤してください。自ら発見する前に教わったら悔しいと思うくらいの主体性を期待します。

活動紹介

遺伝子・細胞レベルの研究のほか、脳を含めた身体各部の間の関係や統合の視点から、身体活動や芸術表現を対象とした研究にも取り組んでいきたい。

教育・研究テーマ

[分野] 分子細胞生物学、脳科学、発生工学(幹細胞)、動物行動学など
[対象]カルシウムチャンネルの生理機能、神経細胞死のメカニズム、細胞の増殖と分化の制御、動的システムのモデリングとダイナミクス、等
細胞内の様々な現象がどの程度どんな文脈で「合目的的」あるいは「中立」なのか。これは広く、自然に対する認識、態度に関係することであると考えている。
これまでの教育・研究活動ついては、研究者データベース(Researchmap)にも記載しています( https://researchmap.jp/Akira29 )。

主な略歴

学位
医学博士(2006年、東京大学 論博)
神戸市出身。
1991年、 東京大学大学院(工学系)修士課程(化学工学専攻) 修了。
塩野義製薬(株)研究員 (1991-1998)、東京大学医科学研究所 研究生 (1996-1998)、科学技術振興機構 研究員 (1998-2005)、
理化学研究所脳科学総合研究センター 研究員 (1999-2005)、順天堂大学老人性疾患病態・治療研究センター 研究員 (2006-2007)、
米国国立衛生研究所 (NIH) 博士研究員 (2007-2010)、等を経て、2010年、神戸市看護大学准教授。2015年4月より現職。

最近の主な研究・論文

論文

  1. Futatsugi A, Kuwajima G, Mikoshiba K. Tissue-specific and developmentally regulated alternative splicing in mouse skeletal muscle ryanodine receptor mRNA. Biochem. J. 305, 373-378 (1995)
  2. Futatsugi A, Kuwajima G, Mikoshiba K. Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor. Biochem. J. 334, 559-563 (1998)
  3. Futatsugi A, Kato K, Ogura H, Li ST, Nagata E, Kuwajima G, Tanaka K, Itohara S, Mikoshiba K. Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3. Neuron 24, 701-713 (1999)
  4. Futatsugi A, Nakamura T, Yamada MK, Ebisui E, Nakamura K, Uchida K, Kitaguchi T, Takahashi-Iwanaga H, Noda T, Aruga J, Mikoshiba K. IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science 309, 2232-2234 (2005)
  5. Futatsugi A, Ebisui E, Mikoshiba K. Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum. J. Neurochem. 105, 1153-1164 (2008).
  6. Futatsugi A, Utreras E, Rudrabhatla P, Jaffe H, Pant HC, Kulkarni AB. Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons. Cell Cycle 11, 1603-1610 (2012)

学会発表

  1. Futatsugi A, Kato K, Ogura H, Mikoshiba K. Facilitated LTP and inhibited LTD in the hippocampus CA1, and altered spatial learning in type 3 ryanodine receptor deficient mice. 1999 Annual Meeting of the Society for Neuroscience. Florida, U.S.A. (1999) (Poster)
  2. Futatsugi A. Regulation of Synaptic Plasticity and Behavior by Intracellular Calcium Release Channels, The 21st Keio Neuroscience Symposium. Tokyo, Japan (2000) (Invited Lecture)
  3. Futatsugi A, Suzuki N, Hashikawa T, Mikoshiba K. Ataxia in mice lacking a1A subunit of P/Q type calcium channels. The 23rd Annual Meeting of the Molecular Biology Society of Japan. Kobe, Japan (2000) (Poster)
  4. Futatsugi A. Roles of calcium channels in brain function. The 78th Annual Meeting of the Physiological Society of Japan. Kyoto, Japan (2001) (Oral)
  5. Futatsugi A, Suzuki N, Mikoshiba K. Generation of Cre recombinase transgenic mice for central nervous system-specific gene knockout. The 44th Annual Meeting of the Japanese Society for Neurochemistry. Kyoto, Japan (2001) (Poster)
  6. Futatsugi A, Coutinho V, Miyawaki A, Itohara S, Knoepfel T, Mikoshiba K. Optical imaging of cellular responses using calcium-sensing, yellow cameleon transgenic mice. 2002 Annual Meeting of the Society for Neuroscience. Florida, U.S.A. (2002) (Poster)
  7. Futatsugi A. Physiological roles of type 2 and type 3 IP3 receptors “What knockout mice tell us”. International Symposium on Calcium Oscillation: Molecular Mechanisms and Medical Applications of an Extraordinary Versatile Cell Signal". Nobel Forum, Stockholm, Sweden (2003) (Oral)
  8. Futatsugi A, Nakamura T, Ebisui E, Nakamura K, Mikoshiba K. Roles of type 2 and type 3 IP3 receptors in exocrine secretion. The 82nd Annual Meeting of the Physiological Society of Japan. Sendai, Japan (2005) (Poster)
  9. Futatsugi A, Ebisui E, Mikoshiba K. Type 2 and type 3 IP3 receptors promote the differentiation of granule cell precursors in the postnatal cerebellum. 2008 Annual Meeting of the Society for Neuroscience. Washington D.C., U.S.A. (2008) (Poster)
  10. Futatsugi A, Utreras E, Rudrabhatla P, Jaffe H, Pant HC, Kulkarni AB. Cdk5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons. The 55th Annual Meeting of the Japanese Society of Neurochemistry. Kobe, Japan (2012) (Poster)

所属学会

  • 日本生理学会
  • 日本分子生物学会
  • 日本生物物理学会
  • 日本神経化学会
  • 北米神経科学会 (Society for Neuroscience)

学部授業

  • (学部)
  • 人体機能論
  • 看護病態学II
  • 薬理学I
  • 薬理学II
  • スタートアップセミナー
  • 研究演習
  • 臨床遺伝学(コーディネータ)

大学院授業

  • がんの分子生物学
  • 科学論文精読

Akira Futatsugi

Basic Medical Sciences RegionMedical Science DivisionProfessor
E-mail
futatsugiNo spam@tr.kobe-ccn.ac.jp

Education & Work experience

Academic degree
Ph.D.
1967 Born in Kobe, Japan.
1989 B. Eng., Dept. Chem. Eng., Univ. of Tokyo
1991 M. Eng., Dept. Chem. Eng., Univ. of Tokyo
1991-1998 Research Scientist, Shionogi Inst. Med. Sci., Shionogi & Co., Ltd.
1995 Research Fellow, Inst. Virus Res., Kyoto Univ.
1996-1998 Research Student, Inst. Med. Sci., Univ. of Tokyo
1998-2000 Research Scientist (Deputy Group Leader), Mikoshiba Project, ERATO, JST
1998-1999 Visiting Researcher, RIKEN Tsukuba Life Sci. Center
1999-2005 Visiting Researcher, RIKEN Brain Sci. Inst.
2001-2005 Research Scientist, Calcium Oscillation Project, ICORP, JST
2006 Ph.D. in Med. Sci., Univ. of Tokyo
2006-2007 Research Scientist, Res. Inst. Disease of Old Age, Juntendo Univ. Sch. Med.
2007-2010 Postdoctoral Fellow, NIDCR, National Institutes of Health (NIH), USA
2010-2015 Associate Professor, Dept. Basic Med. Sci., Kobe City College of Nursing
2011- Lecturer (part-time), Konan Women's University
2015- Professor, Dept. Basic Med. Sci., Kobe City College of Nursing

Publications

Articles

  1. Futatsugi A, Kuwajima G, Mikoshiba K. Tissue-specific and developmentally regulated alternative splicing in mouse skeletal muscle ryanodine receptor mRNA. Biochem. J. 305, 373-378 (1995)
  2. Futatsugi A, Kuwajima G, Mikoshiba K. Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor. Biochem. J. 334, 559-563 (1998)
  3. Futatsugi A, Kato K, Ogura H, Li ST, Nagata E, Kuwajima G, Tanaka K, Itohara S, Mikoshiba K. Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3. Neuron 24, 701-713 (1999)
  4. Futatsugi A, Nakamura T, Yamada MK, Ebisui E, Nakamura K, Uchida K, Kitaguchi T, Takahashi-Iwanaga H, Noda T, Aruga J, Mikoshiba K. IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science 309, 2232-2234 (2005)
  5. Futatsugi A, Ebisui E, Mikoshiba K. Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum. J. Neurochem. 105, 1153-1164 (2008).
  6. Futatsugi A, Utreras E, Rudrabhatla P, Jaffe H, Pant HC, Kulkarni AB. Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons. Cell Cycle 11, 1603-1610 (2012)

Oral presentations

  1. Futatsugi A, Kato K, Ogura H, Mikoshiba K. Facilitated LTP and inhibited LTD in the hippocampus CA1, and altered spatial learning in type 3 ryanodine receptor deficient mice. 1999 Annual Meeting of the Society for Neuroscience. Florida, U.S.A. (1999) (Poster)
  2. Futatsugi A. Regulation of Synaptic Plasticity and Behavior by Intracellular Calcium Release Channels, The 21st Keio Neuroscience Symposium. Tokyo, Japan (2000) (Invited Lecture)
  3. Futatsugi A, Suzuki N, Hashikawa T, Mikoshiba K. Ataxia in mice lacking a1A subunit of P/Q type calcium channels. The 23rd Annual Meeting of the Molecular Biology Society of Japan. Kobe, Japan (2000) (Poster)
  4. Futatsugi A. Roles of calcium channels in brain function. The 78th Annual Meeting of the Physiological Society of Japan. Kyoto, Japan (2001) (Oral)
  5. Futatsugi A, Suzuki N, Mikoshiba K. Generation of Cre recombinase transgenic mice for central nervous system-specific gene knockout. The 44th Annual Meeting of the Japanese Society for Neurochemistry. Kyoto, Japan (2001) (Poster)
  6. Futatsugi A, Coutinho V, Miyawaki A, Itohara S, Knoepfel T, Mikoshiba K. Optical imaging of cellular responses using calcium-sensing, yellow cameleon transgenic mice. 2002 Annual Meeting of the Society for Neuroscience. Florida, U.S.A. (2002) (Poster)
  7. Futatsugi A. Physiological roles of type 2 and type 3 IP3 receptors “What knockout mice tell us”. International Symposium on Calcium Oscillation: Molecular Mechanisms and Medical Applications of an Extraordinary Versatile Cell Signal". Nobel Forum, Stockholm, Sweden (2003) (Oral)
  8. Futatsugi A, Nakamura T, Ebisui E, Nakamura K, Mikoshiba K. Roles of type 2 and type 3 IP3 receptors in exocrine secretion. The 82nd Annual Meeting of the Physiological Society of Japan. Sendai, Japan (2005) (Poster)
  9. Futatsugi A, Ebisui E, Mikoshiba K. Type 2 and type 3 IP3 receptors promote the differentiation of granule cell precursors in the postnatal cerebellum. 2008 Annual Meeting of the Society for Neuroscience. Washington D.C., U.S.A. (2008) (Poster)
  10. Futatsugi A, Utreras E, Rudrabhatla P, Jaffe H, Pant HC, Kulkarni AB. Cdk5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons. The 55th Annual Meeting of the Japanese Society of Neurochemistry. Kobe, Japan (2012) (Poster)

Affiliated academic organization(s)

  • Physiological Society of Japan
  • The Molecular Biology Society of Japan
  • The Biophysical Society of Japan
  • The Japanese Society foe Neurochemistry
  • Society for Neuroscience (SfN)

Lesson

  • Physiology
  • Pharmacology
  • Pathophysiology

Lesson in Graduate school

  • Cell Biology of Cancer
  • Critical Reading of Scientific Papers